Nature

Expeditious Synthesis of Spiroindoline Derivatives via Tandem C(sp2)–H and C(sp3)–H Bond Functionalization of N-Methyl-N-nitrosoanilines

The Nature Index 2024 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...
Nature

Catalyst-Free gem-Difluorination/Spirocyclization of Indole-2-carboxamides: Synthesis of C2-Spiroindoline Derivatives

The Nature Index 2024 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...
EurekAlert!

Synthesis of seven quebracho indole alkaloids using "antenna ligands" in 7-10 steps, including three first-ever asymmetric syntheses

Professor Lijia Wang's group at East China Normal University, in collaboration with Academician Yong Tang of the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, developed a ...
BioWorld

MDM2 inhibitor shows efficacy in wild-type p53 cancer models

Researchers from the Chinese Academy of Sciences and collaborators reported on the discovery and preclinical characterization of JN-122, a potent spiroindoline derivative that showed a Ki value of 0.7 ...