G protein-coupled receptors (GPCRs) represent a large and versatile family of membrane proteins that transduce extracellular signals into intracellular responses. In the context of energy homeostasis ...

A recent study published in Engineering delves into the complex mechanisms of drug addiction, highlighting the crucial role of astrocytic G protein-coupled receptors (GPCRs). This research offers ...

A GPS-like technique has been used to track G protein-coupled receptor movement, revealing how these essential receptors function. Although G protein-coupled receptors (GPCRs) are crucial to the ...

A recent study published in Nature by a research team from the United States and China introduced a new class of engineered G ...

During lactation, the mammary gland undergoes significant structural and functional changes to produce milk, which is ...

G protein-coupled receptors (GPCRs) are the largest family of human proteins. They have a common structure and, signaling through a much smaller set of G proteins, arrestins, and effectors, activate ...

This new article publication from Acta Pharmaceutica Sinica B, discusses allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Neuropathic pain is a ...

In recent years, it has become evident that cell metabolism shapes and is shaped by immune responses highlighting cell metabolism as therapeutic target to ...

If future studies confirm the rescued receptors work normally, the study offers a new roadmap for rare disease drug development.

From September 1, 2021, to March 23, 2022, 33 patients were infused with anti-GPRC5D CAR T cells. At a median follow-up of 5.2 months (range, 3.2‐8.9), the overall response rate was 91% (95% CI, 76 to ...

A publication from Acta Pharmaceutica Sinica B discusses allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Neuropathic pain is a debilitating ...