Computational models of the glucoregulatory system constitute a powerful tool for preclinical evaluation and mechanistic insight into therapeutics. However, in the case of diabetes, there is a dearth ...

l-Serine, a nonessential amino acid in humans, possesses significant physiological functions and is widely used in the food, cosmetic, and pharmaceutical industries. Driven by steadily growing market ...

This study discovered a new thermocatalytic reaction of NO-to-NH3 synthesis to solve nitric oxide pollution and low NH3 synthesis efficiency. Solid-solution OsxPt1–x/γ-Al2O3 exhibited an outstanding ...

A facile asymmetric synthesis of α,α-disubstituted amino acid derivatives was achieved via gold redox catalysis. The in situ formed aryl gold(III) served as the key intermediate toward alkyne ...

Au nanoclusters (NCs), with discrete electronic structures and tunable properties, are promising building blocks for nanoelectronics. However, maximizing their potential requires a deeper ...

The high clinical failure rate of small-molecule drugs is inarguably attributable to the lack of reliable predictions of chemical structure–efficacy–toxicity relationships that are applicable to ...

Correction to “Stealth Polydopamine-Based Nanoparticles with Red Blood Cell Membrane for the Chemo-Photothermal Therapy of Cancer” ...

The potential toxicities of chemicals to humans and wildlife remain largely unknown. In vitro bioassays have increasingly been applied for the toxicity testing of chemicals. However, most of these ...

Noncanonical nucleic acid conformations like G-quadruplexes and i-motifs are key regulators of gene function, genome stability, and drug action. Their structural dynamics in extreme conditions of high ...

We herein disclose a mild and efficient cadmium-catalyzed domino reaction for accessing 1,6-enynes via a sequential A 3 -coupling/1,5-hydride transfer/hydrolysis/A 3 -coupling. This method ...

Understanding the correlation between interdot spacing and their interactions is crucial for controlling the properties of quantum dot superlattices. In this study, the interdot spacing of the ...

Protein–ligand binding affinity may be affected by protein mutations, especially point mutations occurring within the binding site, which may indirectly contribute to interindividual differences in ...