Four pillars of heart failure: contemporary ... - Open Heart
Mar 2, 2021 · The past two decades have heralded dramatic improvements in outcomes for people living with heart failure with reduced ejection fraction (HFrEF). 1 The more widespread implementation of disease modifying pharmacological therapies,2 supported by landmark trials of renin-angiotensin system inhibitors3 and beta-blockers4 have improved longevity despite a background of an ageing and increasingly ...
Harnessing the power of clinical decision support systems: …
Nov 28, 2023 · Clinical decision support systems (CDSSs) are increasingly integrated into healthcare settings to improve patient outcomes, reduce medical errors and enhance clinical efficiency by providing clinicians with evidence-based recommendations at the point of care. However, the adoption and optimisation of these systems remain a challenge. This review aims to provide an overview of the current state ...
Vitamin K2—a neglected player in cardiovascular health: a …
Nov 16, 2021 · Vitamin K2 serves an important role in cardiovascular health through regulation of calcium homeostasis. Its effects on the cardiovascular system are mediated through activation of the anti-calcific protein known as matrix Gla protein. In its inactive form, this protein is associated with various markers of cardiovascular disease including increased arterial …
Myo-inositol for insulin resistance, metabolic syndrome, polycystic ...
Mar 2, 2022 · Myo-inositol, also known as inositol (cyclohexanehexol), is a cyclic carbohydrate with six hydroxyl groups.1 For a long time, it was considered a B vitamin (vitamin B8). However, it is not considered an essential nutrient because it is formed from glucose. Each kidney makes around 2 g of myo-inositol per day, and the average dietary intake is 0.5–1.0 g/day.2 3 The liver and brain also ...
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Open Heart is dedicated to publishing high quality, peer reviewed medical research in all disciplines and therapeutic areas of cardiovascular medicine. Research is published across all study phases and designs, from protocols to phase I trials to meta-analyses, including small or specialist studies. Opinionated discussions on controversial ...
Echocardiographic diagnosis of right-to-left shunt using ...
Introduction. Patent foramen ovale (PFO) is a common finding with a prevalence of about 25% in the general population.1 A strong association between PFO and ischaemic stroke has been reported.2 Pulmonary arteriovenous malformation (PAVM) is a rare disease in the general population and causes a permanent right-to-left shunt (RLS).3 The association of pulmonary RLS grade on contrast ...
Transcatheter tricuspid valve intervention techniques and …
Severe tricuspid regurgitation (TR) is an undertreated common pathology associated with significant morbidity and mortality. Classically, surgical repair or valve replacement were the only therapeutic options and are associated with up to 10% postprocedural mortality. Transcatheter tricuspid valve interventions are a novel and effective therapeutic option for the treatment of significant TR ...
Transcatheter mitral valve repair: an overview of current and future ...
Apr 28, 2021 · The field of transcatheter mitral valve repair (TMVr) for mitral regurgitation (MR) is rapidly evolving. Besides the well-established transcatheter mitral edge-to-edge repair approach, there is also growing evidence for therapeutic strategies targeting the mitral annulus and mitral valve chordae. A patient-tailored approach, careful patient selection and an experienced interventional team is ...
Amlodipine in hypertension: a first-line agent with efficacy for ...
Sep 28, 2016 · Objectives Hypertension is well established as a major risk factor for cardiovascular disease. Although there is undeniable evidence to support the beneficial effects of antihypertensive therapy on morbidity and mortality, adequate blood pressure management still remains suboptimal. Research into the treatment of hypertension has produced a multitude of drug classes with different efficacy ...
Clinical, functional and prognostic implications of severe atrial ...
Objective Atrial dilation is known to be a poor prognostic indicator. However, its clinical, functional and prognostic implications have not been thoroughly explored in secondary mitral regurgitation (SMR). We sought to describe the implications of severe atrial dilation (SAD) in SMR.Methods We included all adult patients with severe SMR due to left ventricle dysfunction (with no organic ...