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45K views · 570 reactions | Methylene Blue is the coolest nam…
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The Knoevenagel condensation elegantly constructs carbon–carbon bonds by coupling an active methylene compound with an aldehyde or ketone in the presence of a mild base such as piperidine or pyridine. Developed by Emil Knoevenagel in the late nineteenth century, this transformation broadened the synthetic landscape by enabling efficient formation of α,β-unsaturated carbonyl compounds under mild, operationally simple conditions. Its broad functional-group tolerance make it indispensable for prepa
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The Knoevenagel condensation elegantly constructs carbon–carb…
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